SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: automated matches

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 2137177Protein automated matches [190514] (11 species)
    not a true protein

Species:

  1. 2137178Escherichia coli [TaxId:562] [187587] (3 PDB entries)
    1. Domains for 2d0k:
      1. 2137179Domain d2d0ka_: 2d0k A: [163534]
        automated match to d1ddra_
        complexed with cl, fol; mutant
      2. 2137180Domain d2d0kb_: 2d0k B: [163535]
        automated match to d1ddra_
        complexed with cl, fol; mutant
    2. Domain for 4p66:
    3. Domain for 4p68:
  2. 2137183Human (Homo sapiens) [TaxId:9606] [188894] (2 PDB entries)
    1. Domain for 3n0h:
    2. Domain for 3s3v:
  3. 2137186Klebsiella pneumoniae [TaxId:1244085] [261371] (2 PDB entries)
    1. Domain for 4or7:
    2. Domains for 4osg:
      1. 2137188Domain d4osga_: 4osg A: [261862]
        automated match to d3k74a_
        complexed with 06u, ca, cac, cl, eoh, nap, peg
      2. 2137189Domain d4osgb_: 4osg B: [261863]
        automated match to d3k74a_
        complexed with 06u, ca, cac, cl, eoh, nap, peg
      3. 2137190Domain d4osgc_: 4osg C: [261866]
        automated match to d3k74a_
        complexed with 06u, ca, cac, cl, eoh, nap, peg
      4. 2137191Domain d4osgd_: 4osg D: [261865]
        automated match to d3k74a_
        complexed with 06u, ca, cac, cl, eoh, nap, peg
  4. 2137192Mycobacterium avium [TaxId:1764] [189124] (2 PDB entries)
    1. Domain for 2w3v:
    2. Domain for 2w3w:
  5. 2137195Plasmodium vivax [TaxId:5855] [187469] (4 PDB entries)
    1. Domain for 2bl9:
    2. Domain for 2bla:
    3. Domain for 2blb:
    4. Domain for 2blc:
  6. 2137200Pneumocystis jirovecii [TaxId:42068] [197174] (1 PDB entry)
  7. 2137202Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)
    1. Domains for 3lg4:
      1. 2137209Domain d3lg4a_: 3lg4 A: [247454]
        automated match to d4fgga_
        complexed with 52v, ndp; mutant
      2. 2137210Domain d3lg4b_: 3lg4 B: [247455]
        automated match to d4fgga_
        complexed with 52v, ndp; mutant
    2. Domains for 3sgy:
      1. 2137205Domain d3sgya_: 3sgy A: [200656]
        automated match to d3sgyb_
        complexed with 06w, ndp
      2. 2137206Domain d3sgyb_: 3sgy B: [195886]
        automated match to d3fywx_
        complexed with 06w, ndp
    3. Domains for 3sh2:
      1. 2137207Domain d3sh2a_: 3sh2 A: [249450]
        automated match to d3fywx_
        complexed with 5dr, ndp
      2. 2137208Domain d3sh2b_: 3sh2 B: [249451]
        automated match to d3fywx_
        complexed with 5dr, ndp
    4. Domain for 4fgg:
    5. Domain for 4fgh:
  8. 2137211Staphylococcus aureus [TaxId:273036] [274776] (1 PDB entry)
  9. 2271411Yersinia pestis [TaxId:214092] [314715] (1 PDB entry)
  10. 2284213Mycobacterium tuberculosis [TaxId:1773] [327514] (2 PDB entries)
    1. Domain for 5u26:
    2. Domain for 5u27:
  11. 2286058Mycobacterium tuberculosis [TaxId:83332] [329359] (1 PDB entry)

More info for Protein automated matches from c.71.1.1: Dihydrofolate reductases

Timeline for Protein automated matches from c.71.1.1: Dihydrofolate reductases: