SCOPe 2.01: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.01
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein automated matches [190098] (3 species)
not a true protein
Species Human (Homo sapiens) [TaxId:9606] [186820] (5 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1wci:
- Domain d1wcia_: 1wci A: [120890]
  Other proteins in same PDB: d1wcib1, d1wcib2
  automated match to d1olxa_
  complexed with cl, gol, k, mn, wwf
Domain(s) for 2beu:
- Domain d2beua_: 2beu A: [128389]
  Other proteins in same PDB: d2beub1, d2beub2
  automated match to d1olxa_
  complexed with cl, gol, k, mn, so4, thv
Domain(s) for 2bev:
- Domain d2beva_: 2bev A: [128392]
  Other proteins in same PDB: d2bevb1, d2bevb2
  automated match to d1olxa_
  complexed with cl, gol, k, mn, thy
Domain(s) for 2bew:
- Domain d2bewa_: 2bew A: [128395]
  Other proteins in same PDB: d2bewb1, d2bewb2
  automated match to d1olxa_
  complexed with cl, gol, k, mn, thw
Domain(s) for 2j9f:
1. Domain d2j9fa_: 2j9f A: [165952]
  automated match to d1olxa_
  complexed with gol, k, mn, thv
2. Domain d2j9fc_: 2j9f C: [165953]
  automated match to d1olxa_
  complexed with gol, k, mn, thv

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 automated matches

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 automated matches:

Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 automated matches is new in SCOPe 2.01-stable
Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 automated matches appears in SCOPe 2.02
Species Human (Homo sapiens) [TaxId:9606] from c.36.1.11 automated matches appears in the current release, SCOPe 2.08