Lineage for d3zrka_ (3zrk A:)

  1. Root: SCOPe 2.02
  2. 1190016Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1220003Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1220004Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1220070Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1220799Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  7. 1220800Species Human (Homo sapiens) [TaxId:9606] [69824] (23 PDB entries)
    Uniprot P49841 35-383 ! Uniprot P49841 35-384
  8. 1220811Domain d3zrka_: 3zrk A: [186533]
    automated match to d1j1bb_
    complexed with gol, so4, zrk

Details for d3zrka_

PDB Entry: 3zrk (more details), 2.37 Å

PDB Description: Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d3zrka_:

Sequence, based on SEQRES records: (download)

>d3zrka_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpv
iyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvs
yicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgt
ptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleac
ahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

Sequence, based on observed residues (ATOM records): (download)

>d3zrka_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffysskkdevylnlvldyvpetvyrvarhysrakqtlpviy
vklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyi
csryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtpt
reqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacah
sffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

SCOPe Domain Coordinates for d3zrka_:

Click to download the PDB-style file with coordinates for d3zrka_.
(The format of our PDB-style files is described here.)

Timeline for d3zrka_: