SCOPe 2.08: Domain d3ri3a_: 3ri3 A:

Lineage for d3ri3a_ (3ri3 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein automated matches [190085] (59 species)
   not a true protein

7. Species Streptomyces coelicolor [TaxId:1902] [189970] (5 PDB entries)

8. Domain d3ri3a_: 3ri3 A: [184978]
   Other proteins in same PDB: d3ri3b2
   automated match to d1w4zb_
   complexed with emo, ndp; mutant

Details for d3ri3a_

PDB Entry: 3ri3, 2.29 Å

PDB Description: actinorhodin polyketide ketoreductase mutant p94l bound to nadph and the inhibitor emodin

PDB Compounds: (A:) ketoacyl reductase

SCOPe Domain Sequences for d3ri3a_:

Sequence; same for both SEQRES and ATOM records:

>d3ri3a_ c.2.1.2 (A:) automated matches {Streptomyces coelicolor [TaxId: 1902]}
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrlgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny

Timeline for d3ri3a_:

• d3ri3a_ first appeared in SCOPe 2.01
  
• d3ri3a_ appears in SCOPe 2.07