SCOPe 2.03: Domain d3ptga_: 3ptg A:

Lineage for d3ptga_ (3ptg A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (26 PDB entries)

8. Domain d3ptga_: 3ptg A: [183972]
   automated match to d1jnka_
   complexed with 932

Details for d3ptga_

PDB Entry: 3ptg, 2.43 Å

PDB Description: Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor

PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d3ptga_:

Sequence, based on SEQRES records:

>d3ptga_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
nqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqtha
krayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldher
msyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvv
tryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpe
fmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpa
krisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmns

Sequence, based on observed residues (ATOM records):

>d3ptga_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
nqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqtha
krayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldher
msyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglavtryyrapevilgm
gykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyv
enrpkyagltfpklfpdslfpahnklkasqardllskmlvidpakrisvddalqhpyinv
wydpaeveapppqiydkqlderehtieewkeliykevmns

Timeline for d3ptga_:

• d3ptga_ first appeared in SCOPe 2.01
  
• d3ptga_ appears in SCOPe 2.02
  
• d3ptga_ appears in SCOPe 2.04
  
• d3ptga_ appears in the current release, SCOPe 2.08