SCOPe 2.08: Domain d3pj8a1: 3pj8 A:1-298

Lineage for d3pj8a1 (3pj8 A:1-298)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d3pj8a1: 3pj8 A:1-298 [183791]
   Other proteins in same PDB: d3pj8a2
   automated match to d1aq1a_
   complexed with 404

Details for d3pj8a1

PDB Entry: 3pj8, 1.96 Å

PDB Description: Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d3pj8a1:

Sequence, based on SEQRES records:

>d3pj8a1 d.144.1.7 (A:1-298) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d3pj8a1 d.144.1.7 (A:1-298) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkiretegvpstaireisllkelnhpni
vklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpqnllintegaikladfglarafgvvvtlwyrapeillgckyystavdiwslgc
ifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskv
vppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d3pj8a1:

• d3pj8a1 first appeared in SCOPe 2.01, called d3pj8a_
  
• d3pj8a1 appears in SCOPe 2.07