SCOPe 2.03: Domain d3ow4a_: 3ow4 A:

Lineage for d3ow4a_ (3ow4 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d3ow4a_: 3ow4 A: [183329]
   automated match to d1o6ka_
   complexed with smy

Details for d3ow4a_

PDB Entry: 3ow4, 2.6 Å

PDB Description: Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

PDB Compounds: (A:) RAC-alpha serine/threonine-protein kinase

SCOPe Domain Sequences for d3ow4a_:

Sequence, based on SEQRES records:

>d3ow4a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rvtmnefeylkllgkgtfgkvilvkekatgryyamkilkkevivakdevahtltenrvlq
nsrhpfltalkysfqthdrlcfvmeyanggelffhlsrervfsedrarfygaeivsaldy
lhseknvvyrdlklenlmldkdghikitdfglckegikdgatmktfcgtpeylapevled
ndygravdwwglgvvmyemmcgrlpfynqdheklfelilmeeirfprtlgpeaksllsgl
lkkdpkqrlgggsedakeimqhrffagivwqhvyekklsppfkpqvtsetdtryfdeeft
aqmititppdqddsmecvdserrphfpqfdysass

Sequence, based on observed residues (ATOM records):

>d3ow4a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rvtmnefeylkllgkgtfgkvilvkekatgryyamkilkkevivakdevahtltenrvlq
nsrhpfltalkysfqthdrlcfvmeyanggelffhlsrervfsedrarfygaeivsaldy
lhseknvvyrdlklenlmldkdghikitdfglckegikdgatmktfcgtpeylapevled
ndygravdwwglgvvmyemmcgrlpfynqdheklfelilmeeirfprtlgpeaksllsgl
lkkdpkqrlgggsedakeimqhrffagivwqhvyekklsppfkpqvtsetdtryfdeeft
aqmitrphfpqfdysass

Timeline for d3ow4a_:

• d3ow4a_ first appeared in SCOPe 2.01
  
• d3ow4a_ appears in SCOPe 2.02
  
• d3ow4a_ appears in SCOPe 2.04
  
• d3ow4a_ appears in the current release, SCOPe 2.08