SCOPe 2.03: Domain d3nusa_: 3nus A:

Lineage for d3nusa_ (3nus A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d3nusa_: 3nus A: [182567]
   automated match to d1h1wa_
   complexed with gol, jnz, so4

Details for d3nusa_

PDB Entry: 3nus, 2.75 Å

PDB Description: phosphoinositide-dependent kinase-1 (pdk1) with fragment8

PDB Compounds: (A:) phosphoinositide-dependent kinase-1

SCOPe Domain Sequences for d3nusa_:

Sequence, based on SEQRES records:

>d3nusa_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspe
llteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardl
vekllvldatkrlgceemegygplkahpffesvtwenlhqqtppkl

Sequence, based on observed residues (ATOM records):

>d3nusa_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlssfvgtaqyvspellteksack
ssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvlda
tkrlgceemegygplkahpffesvtwenlhqqtppkl

Timeline for d3nusa_:

• d3nusa_ first appeared in SCOPe 2.01
  
• d3nusa_ appears in SCOPe 2.02
  
• d3nusa_ appears in SCOPe 2.04
  
• d3nusa_ appears in the current release, SCOPe 2.08