SCOPe 2.05: Domain d3n84a_: 3n84 A:

Lineage for d3n84a_ (3n84 A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55564] (34 PDB entries)

8. Domain d3n84a_: 3n84 A: [182011]
   automated match to d1fhsa_
   complexed with cl, gol, mg

Details for d3n84a_

PDB Entry: 3n84, 2 Å

PDB Description: Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP

PDB Compounds: (A:) Growth factor receptor-bound protein 2

SCOPe Domain Sequences for d3n84a_:

Sequence; same for both SEQRES and ATOM records:

>d3n84a_ d.93.1.1 (A:) Growth factor receptor-bound protein 2 (GRB2) {Human (Homo sapiens) [TaxId: 9606]}
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

Timeline for d3n84a_:

• d3n84a_ first appeared in SCOPe 2.01
  
• d3n84a_ appears in SCOPe 2.04
  
• d3n84a_ appears in SCOPe 2.06
  
• d3n84a_ appears in the current release, SCOPe 2.08