SCOPe 2.03: Domain d3mgya_: 3mgy A:

Lineage for d3mgya_ (3mgy A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (161 PDB entries)

8. Domain d3mgya_: 3mgy A: [181210]
   automated match to d1a9ua_
   complexed with bog

Details for d3mgya_

PDB Entry: 3mgy, 2.1 Å

PDB Description: mutagenesis of p38 map kinase eshtablishes key roles of phe169 in function and structural dynamics and reveals a novel dfg-out state

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3mgya_:

Sequence, based on SEQRES records:

>d3mgya_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d3mgya_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvggsvcaafdtktglrvavkklsrpfqsiihakrt
yrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvq
fliyqilrglkyihsadiihrdlkpsnlavnedcelkildftrwyrapeimlnwmhynqt
vdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesarnyiqslt
qmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadpy
dqsfesrdllidewksltydevisfvppp

Timeline for d3mgya_:

• d3mgya_ first appeared in SCOPe 2.01
  
• d3mgya_ appears in SCOPe 2.02
  
• d3mgya_ appears in SCOPe 2.04
  
• d3mgya_ appears in the current release, SCOPe 2.08