SCOPe 2.06: Domain d3mecb_: 3mec B:

Lineage for d3mecb_ (3mec B:)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein automated matches [190211] (6 species)
   not a true protein

7. Species Hiv-1 m:b_hxb2r [TaxId:11706] [187165] (10 PDB entries)

8. Domain d3mecb_: 3mec B: [181026]
   Other proteins in same PDB: d3meca1, d3meca2
   automated match to d1c1cb_
   complexed with 65b, so4

Details for d3mecb_

PDB Entry: 3mec, 2.3 Å

PDB Description: HIV-1 Reverse Transcriptase in Complex with TMC125

PDB Compounds: (B:) p51 Reverse transcriptase

SCOPe Domain Sequences for d3mecb_:

Sequence, based on SEQRES records:

>d3mecb_ e.8.1.2 (B:) automated matches {Hiv-1 m:b_hxb2r [TaxId: 11706]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyql

Sequence, based on observed residues (ATOM records):

>d3mecb_ e.8.1.2 (B:) automated matches {Hiv-1 m:b_hxb2r [TaxId: 11706]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
stkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrky
taftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddl
yvgsdleigqhrtkieelrqhllrwgltyelhpdkwtvqpivlpekdswtvndiqklvgk
lnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpsk
dliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpk
fklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d3mecb_:

• d3mecb_ first appeared in SCOPe 2.01
  
• d3mecb_ appears in SCOPe 2.05
  
• d3mecb_ appears in SCOPe 2.07
  
• d3mecb_ appears in the current release, SCOPe 2.08