SCOPe 2.01: Domain d3mapa_: 3map A:

Lineage for d3mapa_ (3map A:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (9 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189131] (2 PDB entries)

8. Domain d3mapa_: 3map A: [180990]
   automated match to d1t09a_
   complexed with ict, nap; mutant

Details for d3mapa_

PDB Entry: 3map, 2.8 Å

PDB Description: crystal structure of homodimeric r132h mutant of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp and isocitrate

PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d3mapa_:

Sequence, based on SEQRES records:

>d3mapa_ c.77.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqak

Sequence, based on observed residues (ATOM records):

>d3mapa_ c.77.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighharatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdk
siedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwye
hrliddmvaqamkseggfiwacknvaqgygslgmmtsvlvcpdgktveaeaahgtvtrhy
rmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkdl
aacikglpnvqrsdylntfefmdklgenlkiklaqak

Timeline for d3mapa_:

• d3mapa_ is new in SCOPe 2.01-stable
  
• d3mapa_ appears in SCOPe 2.02
  
• d3mapa_ appears in the current release, SCOPe 2.08