SCOPe 2.03: Domain d3lw0a_: 3lw0 A:

Lineage for d3lw0a_ (3lw0 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin-like growth factor 1 receptor [69825] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69826] (15 PDB entries)

8. Domain d3lw0a_: 3lw0 A: [180594]
   automated match to d1p4ob_
   complexed with ccx, gol

Details for d3lw0a_

PDB Entry: 3lw0, 1.79 Å

PDB Description: igf-1rk in complex with ligand msc1609119a-1

PDB Compounds: (A:) insulin-like growth factor 1 receptor

SCOPe Domain Sequences for d3lw0a_:

Sequence, based on SEQRES records:

>d3lw0a_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

Sequence, based on observed residues (ATOM records):

>d3lw0a_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpppslsk
miqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgll
pvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkp
dncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

Timeline for d3lw0a_:

• d3lw0a_ first appeared in SCOPe 2.01
  
• d3lw0a_ appears in SCOPe 2.02
  
• d3lw0a_ appears in SCOPe 2.04
  
• d3lw0a_ appears in the current release, SCOPe 2.08