SCOPe 2.08: Domain d3l8xa_: 3l8x A:

Lineage for d3l8xa_ (3l8x A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (204 PDB entries)

8. Domain d3l8xa_: 3l8x A: [180096]
   automated match to d2rg6a_
   complexed with n4d

Details for d3l8xa_

PDB Entry: 3l8x, 2.4 Å

PDB Description: p38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3l8xa_:

Sequence, based on SEQRES records:

>d3l8xa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d3l8xa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvsvcaafdtktglrvavkklsrpfqsiihakrty
relrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkqkltddhvqfl
iyqilrglkyihsadiihrdlkpsnlavnedcelkildfglaratrwyrapeimnqtvdi
wsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkissesarnyiqsltqmp
kmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdpddepvadpydqs
fesrdllidewksltydevisfvppp

Timeline for d3l8xa_:

• d3l8xa_ first appeared in SCOPe 2.01
  
• d3l8xa_ appears in SCOPe 2.07