SCOPe 2.01: Domain d3hmma_: 3hmm A:

Lineage for d3hmma_ (3hmm A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (8 PDB entries)
   Uniprot P36897 200-500 ! Uniprot P36897 201-503

8. Domain d3hmma_: 3hmm A: [177698]
   automated match to d1vjya_
   complexed with 855

Details for d3hmma_

PDB Entry: 3hmm, 1.7 Å

PDB Description: structure of alk5 + gw855857

PDB Compounds: (A:) TGF-beta receptor type-1

SCOPe Domain Sequences for d3hmma_:

Sequence, based on SEQRES records:

>d3hmma_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkryma
pevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsvee
mrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq

Sequence, based on observed residues (ATOM records):

>d3hmma_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiagtkrymapevld
dsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsveemrkvv
ceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq

Timeline for d3hmma_:

• d3hmma_ is new in SCOPe 2.01-stable
  
• d3hmma_ appears in SCOPe 2.02
  
• d3hmma_ appears in the current release, SCOPe 2.08