SCOPe 2.08: Domain d3hkwb_: 3hkw B:

Lineage for d3hkwb_ (3hkw B:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus subtype 1a [TaxId:31646] [189338] (1 PDB entry)

8. Domain d3hkwb_: 3hkw B: [177658]
   automated match to d1nb4a_
   complexed with gol, ix6, so4

Details for d3hkwb_

PDB Entry: 3hkw, 1.55 Å

PDB Description: hcv ns5b genotype 1a in complex with 1,5 benzodiazepine inhibitor 6

PDB Compounds: (B:) NS5B RNA-dependent RNA polymerase

SCOPe Domain Sequences for d3hkwb_:

Sequence, based on SEQRES records:

>d3hkwb_ e.8.1.4 (B:) automated matches {Hepatitis C virus subtype 1a [TaxId: 31646]}
smsyswtgalvtpcaaeeqklpinalsnsllrhhnmvysttsrsacqrqkkvtfdrlqvl
dshyqdvlkevkaaaskvkanllsveeacsltpphsarskfgygakdvrcharkavthin
svwkdlledsvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
klpqavmgssygfqyspgqrveflvqawkskkspmgfsydtrcfdstvtesdirteeaiy
qccdldpqarvaikslterlyvggpltnskgencgyrrcrasgvlttscgntltcyikar
aacraaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlw
armilmthffsvliardqleqaldceiygacysiepldlppiiqrlhglsafslhsyspg
einrvaaclrklgvpplrawrhrarsvrakllsrggraaicgkylfnwavrtklkltpia
aagqldlsgwftagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3hkwb_ e.8.1.4 (B:) automated matches {Hepatitis C virus subtype 1a [TaxId: 31646]}
smsyswtgalvtpcaaeeqklpinalsnsllrhhnmvysttsrsacqrqkkvtfdrlqvl
dshyqdvlkevkaaaskvkanllsveeacsltpphsarskfgygakdvrcharkavthin
svwkdlledsvtpidttimaknevfcvqpgrkparlivfpdlgvrvcekmalydvvsklp
qavmgssygfqyspgqrveflvqawkskkspmgfsydtrcfdstvtesdirteeaiyqcc
dldpqarvaikslterlyvggpltnskgencgyrrcrasgvlttscgntltcyikaraac
raaglqdctmlvcgddlvvicesagvqedaaslrafteamtrysappgdppqpeydleli
tscssnvsvahdgagkrvyyltrdpttplaraawetarhtpvnswlgniimfaptlwarm
ilmthffsvliardqleqaldceiygacysiepldlppiiqrlhglsafslhsyspgein
rvaaclrklgvpplrawrhrarsvrakllsrggraaicgkylfnwavrtklkltpiaaag
qldlsgwftagysggdiyhs

Timeline for d3hkwb_:

• d3hkwb_ first appeared in SCOPe 2.01
  
• d3hkwb_ appears in SCOPe 2.07