SCOPe 2.08: Domain d3gt8c_: 3gt8 C:

Lineage for d3gt8c_ (3gt8 C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d3gt8c_: 3gt8 C: [176982]
   automated match to d1m14a_
   complexed with anp, mg

Details for d3gt8c_

PDB Entry: 3gt8, 2.96 Å

PDB Description: crystal structure of the inactive egfr kinase domain in complex with amp-pnp

PDB Compounds: (C:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3gt8c_:

Sequence, based on SEQRES records:

>d3gt8c_ d.144.1.7 (C:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
pnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkanke
ildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwc
vqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpi
kwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppi
ctidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfy
ralmdeedm

Sequence, based on observed residues (ATOM records):

>d3gt8c_ d.144.1.7 (C:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
pnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkanke
ildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwc
vqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriy
thqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcw
midadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedm

Timeline for d3gt8c_:

• d3gt8c_ first appeared in SCOPe 2.01
  
• d3gt8c_ appears in SCOPe 2.07