SCOPe 2.03: Domain d3g0fb_: 3g0f B:

Lineage for d3g0fb_ (3g0f B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-KIT receptor [103296] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103297] (5 PDB entries)
   Uniprot P10721 547-935

8. Domain d3g0fb_: 3g0f B: [176236]
   automated match to d1t45a_
   complexed with b49, so4; mutant

Details for d3g0fb_

PDB Entry: 3g0f, 2.6 Å

PDB Description: kit kinase domain mutant d816h in complex with sunitinib

PDB Compounds: (B:) Mast/stem cell growth factor receptor

SCOPe Domain Sequences for d3g0fb_:

Sequence, based on SEQRES records:

>d3g0fb_ d.144.1.7 (B:) c-KIT receptor {Human (Homo sapiens) [TaxId: 9606]}
ngnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavk
mlkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflr
rkrdsficsktspaimeddelaldledllsfsyqvakgmaflaskncihrdlaarnillt
hgritkicdfglarhikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwe
lfslgsspypgmpvdskfykmikegfrmlspehapaemydimktcwdadplkrptfkqiv
qliekqise

Sequence, based on observed residues (ATOM records):

>d3g0fb_ d.144.1.7 (B:) c-KIT receptor {Human (Homo sapiens) [TaxId: 9606]}
ngnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavk
mlkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflr
rkrdsfldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdfglarhi
kndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspypgmpvds
kfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqise

Timeline for d3g0fb_:

• d3g0fb_ first appeared in SCOPe 2.01
  
• d3g0fb_ appears in SCOPe 2.02
  
• d3g0fb_ appears in SCOPe 2.04
  
• d3g0fb_ appears in the current release, SCOPe 2.08