SCOPe 2.01: Domain d3fqha_: 3fqh A:

Lineage for d3fqha_ (3fqh A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase SYK [118131] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118132] (8 PDB entries)
   Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

8. Domain d3fqha_: 3fqh A: [175977]
   automated match to d1xbba_
   complexed with 057

Details for d3fqha_

PDB Entry: 3fqh, 2.26 Å

PDB Description: crystal structure of spleen tyrosine kinase complexed with a 2- substituted 7-azaindole

PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d3fqha_:

Sequence, based on SEQRES records:

>d3fqha_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydvv

Sequence, based on observed residues (ATOM records):

>d3fqha_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqqldnpyi
vrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfvh
rdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyykfssk
sdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtyd
venrpgfaavelrlrnyyydvv

Timeline for d3fqha_:

• d3fqha_ is new in SCOPe 2.01-stable
  
• d3fqha_ appears in SCOPe 2.02
  
• d3fqha_ appears in the current release, SCOPe 2.08