SCOPe 2.02: Domain d3fi3a_: 3fi3 A:

Lineage for d3fi3a_ (3fi3 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (24 PDB entries)

8. Domain d3fi3a_: 3fi3 A: [175817]
   automated match to d1jnka_
   complexed with edo, jk2

Details for d3fi3a_

PDB Entry: 3fi3, 2.2 Å

PDB Description: Crystal structure of JNK3 with indazole inhibitor, SR-3737

PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d3fi3a_:

Sequence, based on SEQRES records:

>d3fi3a_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyv
vtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcp
efmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidp
akrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmns

Sequence, based on observed residues (ATOM records):

>d3fi3a_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigivcaaydavldrnvaikklsrpfqnqthakray
relvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyl
lyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglarvtryyrapevilgmgyk
envdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyvenr
pkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyinv
wyppqiydkqlderehtieewkeliykevmns

Timeline for d3fi3a_:

• d3fi3a_ first appeared in SCOPe 2.01
  
• d3fi3a_ appears in SCOPe 2.03
  
• d3fi3a_ appears in the current release, SCOPe 2.08