SCOPe 2.08: Domain d3fi2a_: 3fi2 A:

Lineage for d3fi2a_ (3fi2 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (50 PDB entries)

8. Domain d3fi2a_: 3fi2 A: [175816]
   automated match to d1jnka_
   complexed with edo, jk1

Details for d3fi2a_

PDB Entry: 3fi2, 2.28 Å

PDB Description: Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451

PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d3fi2a_:

Sequence, based on SEQRES records:

>d3fi2a_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyv
vtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcp
efmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidp
akrisvddalqhpyinvwyxxxxxxderehtieewkeliykevmn

Sequence, based on observed residues (ATOM records):

>d3fi2a_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigivcaaydavldrnvaikklsrpfqnqthakray
relvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyl
lyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglarvtryyrapevilgmgyk
envdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyvenr
pkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyinv
wyxxxxxxderehtieewkeliykevmn

Timeline for d3fi2a_:

• d3fi2a_ first appeared in SCOPe 2.01
  
• d3fi2a_ appears in SCOPe 2.07