SCOPe 2.03: Domain d3etaa_: 3eta A:

Lineage for d3etaa_ (3eta A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin receptor [56162] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56163] (16 PDB entries)

8. Domain d3etaa_: 3eta A: [175212]
   automated match to d1gaga_
   complexed with 351

Details for d3etaa_

PDB Entry: 3eta, 2.6 Å

PDB Description: kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor

PDB Compounds: (A:) insulin receptor, kinase domain

SCOPe Domain Sequences for d3etaa_:

Sequence, based on SEQRES records:

>d3etaa_ d.144.1.7 (A:) Insulin receptor {Human (Homo sapiens) [TaxId: 9606]}
evsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesaslrerieflneas
vmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaennpgrppptlqem
iqmaaeiadgmaylnakkfvhrdlaarncmvahdftvkigdfgmtrdiyetdyyrkggkg
llpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdggyld
qpdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfpevsffhseenk

Sequence, based on observed residues (ATOM records):

>d3etaa_ d.144.1.7 (A:) Insulin receptor {Human (Homo sapiens) [TaxId: 9606]}
evsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesaslrerieflneas
vmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaennpgrppptlqem
iqmaaeiadgmaylnakkfvhrdlaarncmvahdftvkigdfgmtrdiyetdyyrkgkgl
lpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdggyldq
pdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfpevsffhseenk

Timeline for d3etaa_:

• d3etaa_ first appeared in SCOPe 2.01
  
• d3etaa_ appears in SCOPe 2.02
  
• d3etaa_ appears in SCOPe 2.04
  
• d3etaa_ appears in the current release, SCOPe 2.08