SCOPe 2.06: Domain d3ekta_: 3ekt A:

Lineage for d3ekta_ (3ekt A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Hiv-1 m:b_arv2/sf2 [TaxId:11685] [187932] (17 PDB entries)

8. Domain d3ekta_: 3ekt A: [175029]
   automated match to d1mt7a_
   complexed with 017, act, po4

Details for d3ekta_

PDB Entry: 3ekt, 1.97 Å

PDB Description: crystal structure of the inhibitor darunavir (drv) in complex with a multi-drug resistant hiv-1 protease variant (l10f/g48v/i54v/v64i/v82a) (refer: flap+ in citation.)

PDB Compounds: (A:) Protease

SCOPe Domain Sequences for d3ekta_:

Sequence; same for both SEQRES and ATOM records:

>d3ekta_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Hiv-1 m:b_arv2/sf2 [TaxId: 11685]}
pqitlwkrpivtiriggqlkealldtgaddtvleemnlpgkwkpkmivgiggfvkvrqyd
qipieicghkaigtvlvgptpaniigrnlltqigctlnf

Timeline for d3ekta_:

• d3ekta_ first appeared in SCOPe 2.01
  
• d3ekta_ appears in SCOPe 2.05
  
• d3ekta_ appears in SCOPe 2.07
  
• d3ekta_ appears in the current release, SCOPe 2.08