SCOPe 2.08: Domain d3ciza1: 3ciz A:2-563

Lineage for d3ciza1 (3ciz A:2-563)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)

8. Domain d3ciza1: 3ciz A:2-563 [173264]
   Other proteins in same PDB: d3ciza2, d3cizb2
   automated match to d1nb4a_
   protein/RNA complex; complexed with sx1, zn

Details for d3ciza1

PDB Entry: 3ciz, 1.87 Å

PDB Description: Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d3ciza1:

Sequence, based on SEQRES records:

>d3ciza1 e.8.1.4 (A:2-563) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvst
lpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyq
ccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasa
acraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydle
litscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwa
rmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspge
inrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipa
asrldlsgwfvagysggdiyhs

Sequence, based on observed residues (ATOM records):

>d3ciza1 e.8.1.4 (A:2-563) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqpegrkparlivfpdlgvrvcekmalydvvstlp
qvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqcc
dlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaac
raaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgein
rvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaas
rldlsgwfvagysggdiyhs

Timeline for d3ciza1:

• d3ciza1 first appeared in SCOPe 2.01, called d3ciza_
  
• d3ciza1 appears in SCOPe 2.07