SCOPe 2.06: Domain d2yc0a_: 2yc0 A:

Lineage for d2yc0a_ (2yc0 A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)

6. Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82196] (34 PDB entries)

8. Domain d2yc0a_: 2yc0 A: [170733]
   automated match to d1iz3a_
   complexed with 2hg, fe2, gol, so4

Details for d2yc0a_

PDB Entry: 2yc0, 2.15 Å

PDB Description: factor inhibiting hif-1 alpha in complex with r-2-hydroxyglutarate

PDB Compounds: (A:) Hypoxia-inducible factor 1-alpha inhibitor

SCOPe Domain Sequences for d2yc0a_:

Sequence; same for both SEQRES and ATOM records:

>d2yc0a_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
maataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelienee
pvvltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnr
eemkfhefveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwg
qltsnllligmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqs
qvdfdnpdyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykga
ptpkrieyplkahqkvaimrniekmlgealgnpqevgpllntmikgryn

Timeline for d2yc0a_:

• d2yc0a_ first appeared in SCOPe 2.01
  
• d2yc0a_ appears in SCOPe 2.05
  
• d2yc0a_ appears in SCOPe 2.07
  
• d2yc0a_ appears in the current release, SCOPe 2.08