SCOPe 2.01: Domain d2xyxa_: 2xyx A:

Lineage for d2xyxa_ (2xyx A:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (97 PDB entries)

8. Domain d2xyxa_: 2xyx A: [170490]
   automated match to d1gwxa_
   complexed with bog, z00

Details for d2xyxa_

PDB Entry: 2xyx, 2.7 Å

PDB Description: novel sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (ppar) gamma-delta agonists with high potency and in-vivo efficacy

PDB Compounds: (A:) Peroxisome proliferator-activated receptor delta

SCOPe Domain Sequences for d2xyxa_:

Sequence, based on SEQRES records:

>d2xyxa_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kafskhiynaylknfnmtkkkarsiltgkashtapfvihdietlwqaekglvwkqlvngl
ppykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamla
sivnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaai
ilcgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaq
mmqrikktetetslhpllqeiykdm

Sequence, based on observed residues (ATOM records):

>d2xyxa_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kafskhiynaylknfnmtkkkarsiltgkapfvihdietlwqaekglvwkqlvnglppyk
eisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasivn
kdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiilcg
drpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmmqr
ikktetetslhpllqeiykdm

Timeline for d2xyxa_:

• d2xyxa_ is new in SCOPe 2.01-stable
  
• d2xyxa_ appears in SCOPe 2.02
  
• d2xyxa_ appears in the current release, SCOPe 2.08