SCOPe 2.05: Domain d2xyjb_: 2xyj B:

Lineage for d2xyjb_ (2xyj B:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (138 PDB entries)

8. Domain d2xyjb_: 2xyj B: [170483]
   automated match to d1gwxa_
   complexed with 1pe, wlm

Details for d2xyjb_

PDB Entry: 2xyj, 2.3 Å

PDB Description: novel sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (ppar) gamma-delta agonists with high potency and in-vivo efficacy

PDB Compounds: (B:) Peroxisome proliferator-activated receptor delta

SCOPe Domain Sequences for d2xyjb_:

Sequence, based on SEQRES records:

>d2xyjb_ a.123.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
adlkafskhiynaylknfnmtkkkarsiltgkashtapfvihdietlwqaekglvwkqlv
nglppykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifa
mlasivnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfi
aaiilcgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvte
haqmmqrikktetetslhpllqeiykdm

Sequence, based on observed residues (ATOM records):

>d2xyjb_ a.123.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
adlkafskhiynaylknfnmtkkkarsiltgtapfvihdietlwqaekglvwglppykei
svhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasivnkd
gllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiilcgdr
pglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmmqrik
ktetetslhpllqeiykdm

Timeline for d2xyjb_:

• d2xyjb_ first appeared in SCOPe 2.01
  
• d2xyjb_ appears in SCOPe 2.04
  
• d2xyjb_ appears in SCOPe 2.06
  
• d2xyjb_ appears in the current release, SCOPe 2.08