SCOPe 2.06: Domain d2xyja_: 2xyj A:

Lineage for d2xyja_ (2xyj A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (173 PDB entries)

8. Domain d2xyja_: 2xyj A: [170482]
   automated match to d1gwxa_
   complexed with 1pe, wlm

Details for d2xyja_

PDB Entry: 2xyj, 2.3 Å

PDB Description: novel sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (ppar) gamma-delta agonists with high potency and in-vivo efficacy

PDB Compounds: (A:) Peroxisome proliferator-activated receptor delta

SCOPe Domain Sequences for d2xyja_:

Sequence, based on SEQRES records:

>d2xyja_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
adlkafskhiynaylknfnmtkkkarsiltgkashtapfvihdietlwqaekglvwkqlv
nglppykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifa
mlasivnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfi
aaiilcgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvte
haqmmqrikktetetslhpllqeiykdm

Sequence, based on observed residues (ATOM records):

>d2xyja_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
adlkafskhiynaylknfnmtkkkarsiltgshtapfvihdietlwqaekglvwkqglpp
ykeisvhvfyrcqcttvetvreltefaksipsfsslflndqvtllkygvheaifamlasi
vnkdgllvangsgfvtreflrslrkpfsdiiepkfefavkfnalelddsdlalfiaaiil
cgdrpglmnvprveaiqdtilralefhlqanhpdaqylfpkllqkmadlrqlvtehaqmm
qrikktetetslhpllqeiykdm

Timeline for d2xyja_:

• d2xyja_ first appeared in SCOPe 2.01
  
• d2xyja_ appears in SCOPe 2.05
  
• d2xyja_ appears in SCOPe 2.07
  
• d2xyja_ appears in the current release, SCOPe 2.08