SCOPe 2.06: Domain d2xrwa1: 2xrw A:2-364

Lineage for d2xrwa1 (2xrw A:2-364)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)

8. Domain d2xrwa1: 2xrw A:2-364 [170334]
   Other proteins in same PDB: d2xrwa2, d2xrwa3
   automated match to d1jnka_
   complexed with anp, gol

Details for d2xrwa1

PDB Entry: 2xrw, 1.33 Å

PDB Description: Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4

PDB Compounds: (A:) Mitogen-activated protein kinase 8

SCOPe Domain Sequences for d2xrwa1:

Sequence, based on SEQRES records:

>d2xrwa1 d.144.1.7 (A:2-364) automated matches {Human (Homo sapiens) [TaxId: 9606]}
srskrdnnfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpf
qnqthakrayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqm
eldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfm
mtpyvvtryyrapevilgmgykenvdiwsvgcimgemikggvlfpgtdhidqwnkvieql
gtpcpefmkklqptvrtyvenrpkyagysfeklfpdvlfpadsehnklkasqardllskm
lvidaskrisvdealqhpyinvwydpseaeapppkipdkqlderehtieewkeliykevm
dle

Sequence, based on observed residues (ATOM records):

>d2xrwa1 d.144.1.7 (A:2-364) automated matches {Human (Homo sapiens) [TaxId: 9606]}
srskrdnnfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpf
qnqthakrayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqm
eldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglryyrapevi
lgmgykenvdiwsvgcimgemikggvlfpgtdhidqwnkvieqlgtpcpefmkklqptvr
tyvenrpkyagysfeklfpdvlfpadsehnklkasqardllskmlvidaskrisvdealq
hpyinvwydpseaeapppkipdkqlderehtieewkeliykevmdle

Timeline for d2xrwa1:

• d2xrwa1 first appeared in SCOPe 2.01, called d2xrwa_
  
• d2xrwa1 was called d2xrwa_ in SCOPe 2.05
  
• d2xrwa1 appears in SCOPe 2.07
  
• d2xrwa1 appears in the current release, SCOPe 2.08