SCOP 1.65: Domain d1iara_: 1iar A:

Lineage for d1iara_ (1iar A:)

1. Root: SCOP 1.65

2. Class a: All alpha proteins [46456] (179 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglments of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (10 proteins)

6. Protein Interleukin-4 (IL-4) [47291] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47292] (13 PDB entries)

8. Domain d1iara_: 1iar A: [16853]
   Other proteins in same PDB: d1iarb1, d1iarb2
   mutant

Details for d1iara_

PDB Entry: 1iar, 2.3 Å

PDB Description: interleukin-4 / receptor alpha chain complex

SCOP Domain Sequences for d1iara_:

Sequence; same for both SEQRES and ATOM records:

>d1iara_ a.26.1.2 (A:) Interleukin-4 (IL-4) {Human (Homo sapiens)}
hkcditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhe
kdtrclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlktim
rekyskcss

Timeline for d1iara_:

• d1iara_ first appeared (with stable ids) in SCOP 1.55
  
• d1iara_ appears in SCOP 1.63
  
• d1iara_ appears in SCOP 1.67
  
• d1iara_ appears in the current release, SCOPe 2.07