SCOPe 2.08: Domain d2rfnb_: 2rfn B:

Lineage for d2rfnb_ (2rfn B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d2rfnb_: 2rfn B: [168089]
   automated match to d1r0pa_
   complexed with am7

Details for d2rfnb_

PDB Entry: 2rfn, 2.5 Å

PDB Description: x-ray structure of c-Met with inhibitor.

PDB Compounds: (B:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d2rfnb_:

Sequence, based on SEQRES records:

>d2rfnb_ d.144.1.7 (B:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
salnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnri
tdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethn
ptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyy
svhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvy
llqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvh

Sequence, based on observed residues (ATOM records):

>d2rfnb_ d.144.1.7 (B:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
salnpelvqavqhvvigpsslivhfnevifgcvyhgtlldndgkkihcavkslnritdig
evsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvk
dligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadpvkwmaleslqtqkftt
ksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevmlkcwhp
kaemrpsfselvsrisaifstfigehyvh

Timeline for d2rfnb_:

• d2rfnb_ first appeared in SCOPe 2.01
  
• d2rfnb_ appears in SCOPe 2.07