SCOPe 2.02: Domain d2qa8a_: 2qa8 A:

Lineage for d2qa8a_ (2qa8 A:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (58 PDB entries)
   Uniprot P03372 307-551

8. Domain d2qa8a_: 2qa8 A: [167490]
   automated match to d1qkua_
   complexed with gen; mutant

Details for d2qa8a_

PDB Entry: 2qa8, 1.85 Å

PDB Description: crystal structure of the estrogen receptor alpha ligand binding domain mutant 537s complexed with genistein

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d2qa8a_:

Sequence, based on SEQRES records:

>d2qa8a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdllleml
dahr

Sequence, based on observed residues (ATOM records):

>d2qa8a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
slalsltadqmvsalldaeppilysefseasmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytfeekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

Timeline for d2qa8a_:

• d2qa8a_ first appeared in SCOPe 2.01
  
• d2qa8a_ appears in SCOPe 2.03
  
• d2qa8a_ appears in the current release, SCOPe 2.08