SCOPe 2.02: Domain d2ilma_: 2ilm A:

Lineage for d2ilma_ (2ilm A:)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (14 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (2 proteins)

6. Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82196] (11 PDB entries)

8. Domain d2ilma_: 2ilm A: [165609]
   automated match to d1iz3a_
   complexed with akg, bct, fe2, gol, so4; mutant

Details for d2ilma_

PDB Entry: 2ilm, 2.3 Å

PDB Description: factor inhibiting hif-1 alpha d201a mutant in complex with fe(ii), alpha-ketoglutarate and hif-1 alpha 35mer

PDB Compounds: (A:) hypoxia-inducible factor 1 alpha inhibitor

SCOPe Domain Sequences for d2ilma_:

Sequence, based on SEQRES records:

>d2ilma_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
avasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdt
nlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhe
fveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnll
ligmegnvtpahyaeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnp
dyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrie
yplkahqkvaimrniekmlgealgnpqevgpllntmikgryn

Sequence, based on observed residues (ATOM records):

>d2ilma_ b.82.2.6 (A:) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
avasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdt
nlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhe
fveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnll
ligmegnvtpahyaeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnp
dyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkiey
plkahqkvaimrniekmlgealgnpqevgpllntmikgryn

Timeline for d2ilma_:

• d2ilma_ first appeared in SCOPe 2.01
  
• d2ilma_ appears in SCOPe 2.03
  
• d2ilma_ appears in the current release, SCOPe 2.08