SCOPe 2.06: Domain d1ya3a_: 1ya3 A:

Lineage for d1ya3a_ (1ya3 A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (173 PDB entries)

8. Domain d1ya3a_: 1ya3 A: [162174]
   automated match to d1m2za_
   complexed with str; mutant

Details for d1ya3a_

PDB Entry: 1ya3, 2.34 Å

PDB Description: crystal structure of the human mineralocorticoid receptor ligand- binding domain bound to progesterone and harboring the s810l mutation responsible for a severe form of hypertension

PDB Compounds: (A:) Mineralocorticoid receptor

SCOPe Domain Sequences for d1ya3a_:

Sequence, based on SEQRES records:

>d1ya3a_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
spvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlple
dqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqis
lqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtkapnnsgq
swqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgna
kplyfh

Sequence, based on observed residues (ATOM records):

>d1ya3a_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
spvmvleniepeivyagydtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitl
iqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvr
lqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtswqrfyqltklld
smhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

Timeline for d1ya3a_:

• d1ya3a_ first appeared in SCOPe 2.01
  
• d1ya3a_ appears in SCOPe 2.05
  
• d1ya3a_ appears in SCOPe 2.07
  
• d1ya3a_ appears in the current release, SCOPe 2.08