SCOPe 2.03: Domain d1sykb_: 1syk B:

Lineage for d1sykb_ (1syk B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein cAMP-dependent PK, catalytic subunit [56116] (4 species)
   AGC group; PKA subfamily; serine/threonine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56119] (24 PDB entries)

8. Domain d1sykb_: 1syk B: [161736]
   automated match to d1cmke_
   mutant

Details for d1sykb_

PDB Entry: 1syk, 2.8 Å

PDB Description: crystal structure of e230q mutant of camp-dependent protein kinase reveals unexpected apoenzyme conformation

PDB Compounds: (B:) cAMP-dependent protein kinase, alpha-catalytic subunit

SCOPe Domain Sequences for d1sykb_:

Sequence, based on SEQRES records:

>d1sykb_ d.144.1.7 (B:) cAMP-dependent PK, catalytic subunit {Mouse (Mus musculus) [TaxId: 10090]}
esvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamk
ildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshl
rrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvk
grtwtlcgtpeylapeiilskgynkavdwwalgvliyqmaagyppffadqpiqiyekivs
gkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkvea
pfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

Sequence, based on observed residues (ATOM records):

>d1sykb_ d.144.1.7 (B:) cAMP-dependent PK, catalytic subunit {Mouse (Mus musculus) [TaxId: 10090]}
esvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamk
ildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshl
rrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvk
grtwtlcgtpeylapeiilskgynkavdwwalgvliyqmaagyppffadqpiqiyekivs
gkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkvea
pfipkeeeeirvsinekcgkeftef

Timeline for d1sykb_:

• d1sykb_ first appeared in SCOPe 2.01
  
• d1sykb_ appears in SCOPe 2.02
  
• d1sykb_ appears in SCOPe 2.04
  
• d1sykb_ appears in the current release, SCOPe 2.08