SCOPe 2.02: Domain d2uzdc_: 2uzd C:

Lineage for d2uzdc_ (2uzd C:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (223 PDB entries)
   Uniprot P24941

8. Domain d2uzdc_: 2uzd C: [161555]
   Other proteins in same PDB: d2uzdb1, d2uzdb2, d2uzdd1, d2uzdd2
   automated match to d1aq1a_
   complexed with c85

Details for d2uzdc_

PDB Entry: 2uzd, 2.72 Å

PDB Description: crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

PDB Compounds: (C:) Cell division protein kinase 2

SCOPe Domain Sequences for d2uzdc_:

Sequence; same for both SEQRES and ATOM records:

>d2uzdc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d2uzdc_:

• d2uzdc_ first appeared in SCOPe 2.01
  
• d2uzdc_ appears in SCOPe 2.03
  
• d2uzdc_ appears in the current release, SCOPe 2.08