SCOPe 2.07: Domain d2o2va_: 2o2v A:

Lineage for d2o2va_ (2o2v A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.2: CAD & PB1 domains [54277] (3 families)
   contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily

5. Family d.15.2.2: PB1 domain [64225] (11 proteins)
   Pfam PF00564
   forms heterodimers, although not all PB1 domain pairs associate.

6. Protein Mitogen activated protein kinase kinase 5, Map2k5 [117827] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142975] (2 PDB entries)
   Uniprot Q13163 4-108

8. Domain d2o2va_: 2o2v A: [161483]
   Other proteins in same PDB: d2o2vb1
   automated match to d2npta1

Details for d2o2va_

PDB Entry: 2o2v, 1.83 Å

PDB Description: crystal structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (map2k5-phox) with human mitogen activated protein kinase kinase kinase 3 (map3k3b-phox)

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 5

SCOPe Domain Sequences for d2o2va_:

Sequence, based on SEQRES records:

>d2o2va_ d.15.2.2 (A:) Mitogen activated protein kinase kinase 5, Map2k5 {Human (Homo sapiens) [TaxId: 9606]}
vlvirikipnsgavdwtvhsgpqllfrdvldvigqvlpeatttafeyededgdritvrsd
eemkamlsyyystvmeqqvngqlieplqifpra

Sequence, based on observed residues (ATOM records):

>d2o2va_ d.15.2.2 (A:) Mitogen activated protein kinase kinase 5, Map2k5 {Human (Homo sapiens) [TaxId: 9606]}
vlvirikipnsgavdwtvhspqllfrdvldvigqvlpeatttafeyededgdritvrsde
emkamlsyyystvmeqqvngqlieplqifpra

Timeline for d2o2va_:

• d2o2va_ first appeared in SCOPe 2.01
  
• d2o2va_ appears in SCOPe 2.06
  
• d2o2va_ appears in the current release, SCOPe 2.08