SCOPe 2.08: Domain d1hvca2: 1hvc A:1A-99A

Lineage for d1hvca2 (1hvc A:1A-99A)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (590 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d1hvca2: 1hvc A:1A-99A [161339]
   synthetic tethered dimer
   complexed with a79

Details for d1hvca2

PDB Entry: 1hvc, 1.8 Å

PDB Description: crystal structure of a tethered dimer of hiv-1 protease complexed with an inhibitor

PDB Compounds: (A:) hiv-1 protease

SCOPe Domain Sequences for d1hvca2:

Sequence; same for both SEQRES and ATOM records:

>d1hvca2 b.50.1.1 (A:1A-99A) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d1hvca2:

• d1hvca2 first appeared in SCOPe 2.01
  
• d1hvca2 appears in SCOPe 2.07