SCOPe 2.03: Domain d3e8db_: 3e8d B:

Lineage for d3e8db_ (3e8d B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Pkb kinase (Akt-2) [82791] (1 species)
   AGC group; RAC/Akt subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82792] (16 PDB entries)

8. Domain d3e8db_: 3e8d B: [158064]
   automated match to d1o6ka_
   complexed with g98

Details for d3e8db_

PDB Entry: 3e8d, 2.7 Å

PDB Description: crystal structures of the kinase domain of akt2 in complex with atp- competitive inhibitors

PDB Compounds: (B:) rac-beta serine/threonine-protein kinase

SCOPe Domain Sequences for d3e8db_:

Sequence, based on SEQRES records:

>d3e8db_ d.144.1.7 (B:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsititppdrydslglleldqrthfpqfdysasir

Sequence, based on observed residues (ATOM records):

>d3e8db_ d.144.1.7 (B:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsiqrthfpqfdysasir

Timeline for d3e8db_:

• d3e8db_ first appeared in SCOP 1.75, called d3e8db1
  
• d3e8db_ appears in SCOPe 2.02
  
• d3e8db_ appears in SCOPe 2.04
  
• d3e8db_ appears in the current release, SCOPe 2.08