SCOPe 2.03: Domain d3bgqa1: 3bgq A:33-305

Lineage for d3bgqa1 (3bgq A:33-305)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
   OPK group(?); PIM subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118134] (59 PDB entries)
   Uniprot P11309 33-305 ! Uniprot P11309 32-308

8. Domain d3bgqa1: 3bgq A:33-305 [155251]
   automatically matched to d1xqza_
   complexed with vx2

Details for d3bgqa1

PDB Entry: 3bgq, 2 Å

PDB Description: Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2

PDB Compounds: (A:) Proto-oncogene serine/threonine-protein kinase Pim-1

SCOPe Domain Sequences for d3bgqa1:

Sequence; same for both SEQRES and ATOM records:

>d3bgqa1 d.144.1.7 (A:33-305) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlh

Timeline for d3bgqa1:

• d3bgqa1 first appeared in SCOP 1.75
  
• d3bgqa1 appears in SCOPe 2.02
  
• d3bgqa1 is called d3bgqa_ in SCOPe 2.04
  
• d3bgqa1 appears in the current release, SCOPe 2.08, called d3bgqa_