SCOPe 2.01: Domain d2zm3b_: 2zm3 B:

Lineage for d2zm3b_ (2zm3 B:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin-like growth factor 1 receptor [69825] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69826] (15 PDB entries)

8. Domain d2zm3b_: 2zm3 B: [154685]
   automated match to d1p4ob_
   complexed with 575

Details for d2zm3b_

PDB Entry: 2zm3, 2.5 Å

PDB Description: Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor

PDB Compounds: (B:) insulin-like growth factor 1 receptor

SCOPe Domain Sequences for d2zm3b_:

Sequence, based on SEQRES records:

>d2zm3b_ d.144.1.7 (B:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
sfsaadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaa
smrerieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpeme
nnpvlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrd
iyetdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsne
qvlrfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsf
yyseen

Sequence, based on observed residues (ATOM records):

>d2zm3b_ d.144.1.7 (B:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
sfsaadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaa
smrerieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpeap
pslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyy
rkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvm
egglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseen

Timeline for d2zm3b_:

• d2zm3b_ first appeared in SCOP 1.75, called d2zm3b1
  
• d2zm3b_ appears in SCOPe 2.02
  
• d2zm3b_ appears in the current release, SCOPe 2.08, called d2zm3b2