SCOPe 2.08: Domain d2z7la_: 2z7l A:

Lineage for d2z7la_ (2z7l A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (58 PDB entries)

8. Domain d2z7la_: 2z7l A: [154199]
   automated match to d1erka_
   complexed with bme, s91, so4

Details for d2z7la_

PDB Entry: 2z7l, 2.41 Å

PDB Description: Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d2z7la_:

Sequence, based on SEQRES records:

>d2z7la_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
vfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreikillr
frheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrgl
kyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrape
imlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciin
lkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyy
dpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records):

>d2z7la_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
vfdvgprytnlsyigegmvcsaydnlnkvrvaikkispfehqtycqrtlreikillrfrh
eniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglkyi
hsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyrapeiml
nskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlka
rnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydps
depiaeapflpkeklkelifeetarfqpg

Timeline for d2z7la_:

• d2z7la_ first appeared in SCOP 1.75, called d2z7la1
  
• d2z7la_ appears in SCOPe 2.07