SCOPe 2.01: Domain d2rewa_: 2rew A:

Lineage for d2rewa_ (2rew A:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor alpha, PPAR-alpha [69109] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69110] (11 PDB entries)

8. Domain d2rewa_: 2rew A: [151991]
   automated match to d1i7ga_
   complexed with cpq, rew

Details for d2rewa_

PDB Entry: 2rew, 2.35 Å

PDB Description: crystal structure of pparalpha ligand binding domain with bms-631707

PDB Compounds: (A:) Peroxisome proliferator-activated receptor alpha

SCOPe Domain Sequences for d2rewa_:

Sequence, based on SEQRES records:

>d2rewa_ a.123.1.1 (A:) Peroxisome proliferator activated receptor alpha, PPAR-alpha {Human (Homo sapiens) [TaxId: 9606]}
etadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvakl
vangiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaif
amlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislf
vaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvt
ehaqlvqiikktesdaalhpllqeiyrdm

Sequence, based on observed residues (ATOM records):

>d2rewa_ a.123.1.1 (A:) Peroxisome proliferator activated receptor alpha, PPAR-alpha {Human (Homo sapiens) [TaxId: 9606]}
etadlkslakriyeaylknfnmnkvkarvilsgppfvihdmetlcmaektlqnkeaevri
fhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifamlssvmnkdgmlv
aygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaaiiccgdrpgll
nvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvtehaqlvqiikktes
daalhpllqeiyrdm

Timeline for d2rewa_:

• d2rewa_ first appeared in SCOP 1.75, called d2rewa1
  
• d2rewa_ appears in SCOPe 2.02
  
• d2rewa_ appears in the current release, SCOPe 2.08