SCOPe 2.01: Domain d2qqnh1: 2qqn H:1-113

Lineage for d2qqnh1 (2qqn H:1-113)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Human (Homo sapiens), cluster 3 [TaxId:9606] [88547] (33 PDB entries)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3)

8. Domain d2qqnh1: 2qqn H:1-113 [151224]
   Other proteins in same PDB: d2qqna_, d2qqnh2
   automatically matched to d1aqkh1
   complexed with edo

Details for d2qqnh1

PDB Entry: 2qqn, 2.2 Å

PDB Description: neuropilin-1 b1 domain in complex with a vegf-blocking fab

PDB Compounds: (H:) antibody heavy chain

SCOPe Domain Sequences for d2qqnh1:

Sequence; same for both SEQRES and ATOM records:

>d2qqnh1 b.1.1.1 (H:1-113) Immunoglobulin heavy chain variable domain, VH {Human (Homo sapiens), cluster 3 [TaxId: 9606]}
evqlvesggglvqpggslrlscaasgftfssyamswvrqapgkglewvsqispaggytny
adsvkgrftisadtskntaylqmnslraedtavyycargelpyyrmskvmdvwgqgtlvt
vss

Timeline for d2qqnh1:

• d2qqnh1 first appeared in SCOP 1.75
  
• d2qqnh1 appears in SCOPe 2.02
  
• d2qqnh1 last appears in SCOPe 2.07