SCOPe 2.03: Domain d2q3za4: 2q3z A:146-461

Lineage for d2q3za4 (2q3z A:146-461)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.4: Transglutaminase core [54044] (3 proteins)

6. Protein Transglutaminase catalytic domain [54045] (4 species)

7. Species Human (Homo sapiens), tissue isozyme [TaxId:9606] [75333] (2 PDB entries)
   GDP-binding protein

8. Domain d2q3za4: 2q3z A:146-461 [150040]
   Other proteins in same PDB: d2q3za1, d2q3za2, d2q3za3
   automatically matched to d1kv3a4
   complexed with so4

Details for d2q3za4

PDB Entry: 2q3z, 2 Å

PDB Description: transglutaminase 2 undergoes large conformational change upon activation

PDB Compounds: (A:) Transglutaminase 2

SCOPe Domain Sequences for d2q3za4:

Sequence, based on SEQRES records:

>d2q3za4 d.3.1.4 (A:146-461) Transglutaminase catalytic domain {Human (Homo sapiens), tissue isozyme [TaxId: 9606]}
davyldseeerqeyvltqqgfiyqgsakfiknipwnfgqfqdgildiclilldvnpkflk
nagrdcsrrsspvyvgrvgsgmvncnddqgvllgrwdnnygdgvspmswigsvdilrrwk
nhgcqrvkygqcwvfaavactvlrclgiptrvvtnynsahdqnsnllieyfrnefgeiqg
dksemiwnfhcwveswmtrpdlqpgyegwqaldptpqeksegtyccgpvpvraikegdls
tkydapfvfaevnadvvdwiqqddgsvhksinrslivglkistksvgrderedithtyky
pegsseereaftranh

Sequence, based on observed residues (ATOM records):

>d2q3za4 d.3.1.4 (A:146-461) Transglutaminase catalytic domain {Human (Homo sapiens), tissue isozyme [TaxId: 9606]}
davyldseeerqeyvltqqgfiyqgsakfiknipwnfgqfqdgildiclilldvnpkflk
nagrdcsrrsspvyvgrvgsgmvncnddqgvllgrwdnnygdgvspmswigsvdilrrwk
nhgcqrvkygqcwvfaavactvlrclgiptrvvtnynsahdsnllieyfrnsemiwnfhc
wveswmtrpdlqpgyegwqaldptpqeksegtyccgpvpvraikegdlstkydapfvfae
vnadvvdwiqksinrslivglkistksvgrderedithtykypegsseereaftranh

Timeline for d2q3za4:

• d2q3za4 first appeared in SCOP 1.75
  
• d2q3za4 appears in SCOPe 2.02
  
• d2q3za4 appears in SCOPe 2.04
  
• d2q3za4 appears in the current release, SCOPe 2.08