SCOP 1.75: Domain d2pi0a1: 2pi0 A:5-110

Lineage for d2pi0a1 (2pi0 A:5-110)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.5: "Winged helix" DNA-binding domain [46785] (84 families)
   contains a small beta-sheet (wing)

5. Family a.4.5.23: Interferon regulatory factor [46877] (3 proteins)
   Pfam PF00605

6. Protein Interferon regulatory factor 3, IRF-3 [116791] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [116792] (3 PDB entries)
   Uniprot Q14653 3-112

8. Domain d2pi0a1: 2pi0 A:5-110 [149489]
   automatically matched to d1t2ka_

Details for d2pi0a1

PDB Entry: 2pi0, 2.31 Å

PDB Description: Crystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer

PDB Compounds: (A:) Interferon regulatory factor 3

SCOP Domain Sequences for d2pi0a1:

Sequence, based on SEQRES records:

>d2pi0a1 a.4.5.23 (A:5-110) Interferon regulatory factor 3, IRF-3 {Human (Homo sapiens) [TaxId: 9606]}
kprilpwlvsqldlgqlegvawvnksrtrfripwkhglrqdaqqedfgifqawaeatgay
vpgrdkpdlptwkrnfrsalnrkeglrlaedrskdphdphkiyefv

Sequence, based on observed residues (ATOM records):

>d2pi0a1 a.4.5.23 (A:5-110) Interferon regulatory factor 3, IRF-3 {Human (Homo sapiens) [TaxId: 9606]}
kprilpwlvsqldlgqlegvawvnksrtrfripwkhglrgifqawaeatgayvpgrdkpd
lptwkrnfrsalnrkeglrlaedrskdphdphkiyefv

Timeline for d2pi0a1:

• d2pi0a1 is new in SCOP 1.75
  
• d2pi0a1 is called d2pi0a_ in SCOPe 2.01
  
• d2pi0a1 appears in the current release, SCOPe 2.08, called d2pi0a_