SCOPe 2.07: Domain d2p16a_: 2p16 A:

Lineage for d2p16a_ (2p16 A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein automated matches [190044] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187233] (166 PDB entries)

8. Domain d2p16a_: 2p16 A: [149154]
   Other proteins in same PDB: d2p16l_
   automated match to d1c5md_
   complexed with ca, gg2

Details for d2p16a_

PDB Entry: 2p16, 2.3 Å

PDB Description: factor xa in complex with the inhibitor apixaban (bms-562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4-c]pyridine-3-carboxamide

PDB Compounds: (A:) Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)

SCOPe Domain Sequences for d2p16a_:

Sequence; same for both SEQRES and ATOM records:

>d2p16a_ b.47.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

Timeline for d2p16a_:

• d2p16a_ first appeared in SCOP 1.75, called d2p16a1
  
• d2p16a_ appears in SCOPe 2.06
  
• d2p16a_ appears in the current release, SCOPe 2.08