SCOP 1.75: Domain d2p16a1: 2p16 A:16-244

Lineage for d2p16a1 (2p16 A:16-244)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Coagulation factor Xa, protease domain [50574] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50575] (75 PDB entries)
   Uniprot P00742 235-467

8. Domain d2p16a1: 2p16 A:16-244 [149154]
   Other proteins in same PDB: d2p16l1
   automatically matched to d1c5md_
   complexed with ca, gg2

Details for d2p16a1

PDB Entry: 2p16, 2.3 Å

PDB Description: factor xa in complex with the inhibitor apixaban (bms-562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4-c]pyridine-3-carboxamide

PDB Compounds: (A:) Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)

SCOP Domain Sequences for d2p16a1:

Sequence; same for both SEQRES and ATOM records:

>d2p16a1 b.47.1.2 (A:16-244) Coagulation factor Xa, protease domain {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

Timeline for d2p16a1:

• d2p16a1 is new in SCOP 1.75
  
• d2p16a1 is called d2p16a_ in SCOPe 2.01
  
• d2p16a1 appears in the current release, SCOPe 2.08, called d2p16a_