SCOPe 2.05: Domain d2jixf2: 2jix F:117-217

Lineage for d2jixf2 (2jix F:117-217)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d2jixf2: 2jix F:117-217 [148116]
   Other proteins in same PDB: d2jixb1, d2jixb2, d2jixc1, d2jixc2, d2jixd1, d2jixe1, d2jixe2, d2jixf1, d2jixh1
   automatically matched to d1h3ph2

Details for d2jixf2

PDB Entry: 2jix, 3.2 Å

PDB Description: crystal structure of abt-007 fab fragment with the soluble domain of epo receptor

PDB Compounds: (F:) abt-007 fab fragment

SCOPe Domain Sequences for d2jixf2:

Sequence; same for both SEQRES and ATOM records:

>d2jixf2 b.1.1.2 (F:117-217) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

Timeline for d2jixf2:

• d2jixf2 first appeared in SCOP 1.75
  
• d2jixf2 appears in SCOPe 2.04
  
• d2jixf2 appears in SCOPe 2.06
  
• d2jixf2 appears in the current release, SCOPe 2.08