SCOPe 2.01: Domain d2iokb_: 2iok B:

Lineage for d2iokb_ (2iok B:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (57 PDB entries)
   Uniprot P03372 307-551

8. Domain d2iokb_: 2iok B: [147748]
   automated match to d1qkua_
   complexed with iok

Details for d2iokb_

PDB Entry: 2iok, 2.4 Å

PDB Description: Human estrogen receptor alpha ligand-binding domain in complex with compound 1D

PDB Compounds: (B:) Estrogen receptor

SCOPe Domain Sequences for d2iokb_:

Sequence, based on SEQRES records:

>d2iokb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydllleml

Sequence, based on observed residues (ATOM records):

>d2iokb_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrasmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihl
makagltlqqqhqrlaqlllilshirhmsnkgmehlysplydllleml

Timeline for d2iokb_:

• d2iokb_ first appeared in SCOP 1.75, called d2iokb1
  
• d2iokb_ appears in SCOPe 2.02
  
• d2iokb_ appears in the current release, SCOPe 2.08